Clinical Evaluation & Recommendations for use
TBS iNsightTM has been evaluated in more than 100 peer-reviewed publications worldwide and on more than 75,000 patients.
TBS has been integrated in 2015 into International and local recommendations: 2015 ISCD Official Position Statements1, ESCEO recommendations2 and DVO Guidelines3.
- TBS is independent and complementary to lumbar spine BMD;
- TBS is associated with fracture risk, in women, in men and in patients with special conditions affecting bone metabolism (rheumatoid arthritis, endocrine diseases or long-term use of glucocorticoids therapy);
- TBS fracture risk prediction ability is equal to lumbar spine BMD;
- TBS is unaffected by the presence of osteophytes – a common artifact in late postmenopausal patients and those presenting with osteoarthritis;
- TBS is reproducible: the short-term reproducibility of TBS determinations has been reported in several studies with values ranging from 1.1%-1.9% C.V.;
- TBS gives lower values in women and in men with previous fragility fractures than their non-fractured counterparts;
- TBS gives lower values in women and in men with previous fragility fractures, but in whom BMD does not indicate osteoporosis or even osteopenia;
- TBS can assist physicians in monitoring the response to treatments over time;
A summary of pivotal studies used in this review appears in the Table below.
Summary of key clinical studies evaluating TBS iNsight
- ISCD (International Society for Clinical Densitometry): Fracture risk prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score, Silva et at., JCD 2015.
- ESCEO (The European Society for Clinical and Economic Aspects of Osteoporosis and osteoarthritis): Trabecular Bone Score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice, Harvey et al., Bone 2015.
- DVO: Dachverband Osteologie – German Osteology Society.
- Silva BC, et al, Trabecular Bone Score: A non-invasive, analytical method based upon the DXA image. J Bone Miner Res 2014; 29(3): 518-530.
- Ulivieri FM, et al, Utility of the trabecular bone score (TBS) in secondary osteoporosis. Endocrine 2014 Nov;47(2):435-48
- Kolta S, et al, TBS result is not affected by lumbar spine osteoarthritis. Osteoporos Int. 2014 Jun; 25(6):1759-64.