Pedrazzoni, M.; Casola, A.; Verzicco, I.; Abbate, B.; Vescovini, R.; Sansoni, P.
PURPOSE: To examine the effects of the menopausal transition and treatment with aromatase inhibitors (AI) on trabecular bone score (TBS, a newly proposed index of bone architecture derived from DXA vertebral scans) and vertebral bone mineral density (BMD). METHODS: Retrospective cohort study on 29 women who became postmenopausal during a mean follow-up of 2.9 years (MP group) and 34 women treated with AI during a mean follow-up of 2.1 years (AI group). BMD was measured by DXA and TBS with a specific software. RESULTS: TBS decreased after menopause, but the change was significantly lower than that of the lumbar BMD (-4.6 vs. -6.8 %, mean difference: 2.2 %, p = 0.016). An even larger difference was observed in the AI group (-2.1 vs. -5.9 %, mean difference: 3.8 %, p = 0.002). CONCLUSIONS: The decrease of TBS induced by menopause or treatment with AI is significantly lower than that of lumbar BMD.