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Kolta, S.; Etcheto, A.; Fechtenbaum, J.; Feydy, A.; Roux, C.; Briot, K.

2018

Purpose/Introduction Measurement of trabecular bone score (TBS®) of the lumbar spine on DXA devices improves fracture risk prediction. We conducted a proof of concept study to assess the feasibility of TBS® measured on the low-dose imaging system EOS®. Methods TBS was assessed on both DXA and EOS® in 122 patients aged ≥ 50 years, receiving no anti-osteoporotic treatment. The TBS® was computed on full-body EOS® images, focusing on the lumbar spine region. The patients were also scanned with a DXA bone densitometer (Hologic) and the spine and hip bone mineral density (BMD, g/cm²) were computed. Results TBS® measurement on EOS® was not possible in 34 patients due to technical problems. It could be measured on both DXA and EOS® in 88 patients (28 with severe low-trauma fracture, and 60 without fracture). TBS-EOS values were significantly lower in fractured patients compared to non-fractured patients. TBS-EOS was associated with the presence of fractures as reported by an AUC of 0.70. Odds ratio of TBS-EOS for the presence of severe low-trauma fracture was 2.00 [1.24 - 3.25], p=0.005. Conclusions This proof of concept study, based on a prototype version of the TBS-EOS, demonstrated the feasibility of the measurement of TBS® on low-dose EOS® imaging devices. Results show that the TBS-EOS was lower in patients with severe low-trauma fractures compared to non-fractured patients independently from BMD. Some technical issues need to be solved before its eventual use in routine clinical settings. Additional prospective studies are still needed to define the actual contribution of this new technique. Mini-abstract This is the first study evaluating the feasibility of the measurement of trabecular bone score (TBS®) of the lumbar spine on the low-dose imaging system (EOS®). Results show that measurement of TBS® on EOS® is feasible. Some technical issues need to be solved before its eventual use in routine clinical settings.

EOS     France     Osteoporosis     Technical study