Authors
Bilezikian, John P.; Silva, Barbara C.; Cusano, Natalie E.
Publication Year
2018
Abstract Note
Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and elevated or inappropriately normal PTH concentrations. The normocalcemic variant of the disease presents with persistently elevated PTH concentrations, but normal levels of ionized and albumin-corrected total calcium. In countries where serum calcium is measured as part of a biochemical-screening panel, PHPT presents primarily as an asymptomatic disease. In parts of the world where calcium is not routinely measured, the disease is more likely to be symptomatic, with skeletal and renal complications. Parathyroidectomy is recommended for those with symptomatic disease, and for those with asymptomatic PHPT who meet guidelines or prefer surgery. This article reviews the current state of the hypercalcemic and normocalcemic variants of PHPT, with particular emphasis on recently published literature.
Journal
Current Opinion in Endocrine and Metabolic Research
Volume
Pages
Pubmed Link