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Rianon, Nahid; Ambrose, Catherine G.; Buni, Maryam; Watt, Gordon; Reyes-Ortiz, Carlos; Lee, Miryoung; McCormick, Joseph; Fisher-Hoch, Susan

2018

Altered bone quality due to the underlying metabolic changes of type 2 diabetes (T2D) has been hypothesized to affect bone strength leading to increased fracture risk in T2D patients. Lumbar spine trabecular bone score (LS-TBS), an indirect measure of trabecular microarchitecture, provides information on bone quality and has been associated with T2D. However, TBS is also affected by demographic patterns and body size, and is expected to be different in people from various ethnic/racial backgrounds. Therefore, it is important to understand associations between T2D and TBS for each ethnic/racial group separately. While the relationship between TBS and age has been reported to be similar between non-Hispanic Caucasians and Mexican Americans (MA), data are lacking on associations of LS-TBS with T2D in older MAs. Here, we report associations between TBS and T2D in 149 older MA men and women. Participants are part of a cohort known as the Cameron County Hispanic Cohort (CCHC) in Texas (TX) who have high prevalence of obesity and poor glycemic control. BMD was not altered for MA women with T2D, but was significantly higher in MA men with T2D compared to MA men without diabetes. Low LS-TBS was associated with T2D in women in our study. While low TBS was associated with older age in men, TBS did not show any significant association with T2D for men. These results are similar to those found in other studies of non-Hispanic Whites with diabetes. LS-TBS may add value in diagnosing poor bone quality in older MA women with T2D regardless of BMD scoring.

Diabetes     Hologic     Mexico     Secondary osteoporosis